Career
In her first film role, Gayheart appeared in Brett Ratner's New York University short film Whatever Happened to Mason Reese? (1990). She also appeared in the Ratner-directed video for Heavy D and the Boyz's song "Nuttin' But Love".
In the early 1990s, Gayheart broke into the television industry with a series of TV commercials for Noxzema, earning her the moniker "The Noxzema Girl". The ads began airing in 1991 and brought her national recognition. In 1992, Gayheart was cast in her first major role, as Hannah Mayberry on the soap opera Loving. In 1993 and 1994, she had a recurring role in the Vanishing Son action series as cellist Clair Rutledge, the love interest of Russell Wong's character Jian-Wa Chang. In 1994 and 1995, Gayheart played Bess Martin in the science-fiction series Earth 2. In 1995, she played Antonia Marchette, a recurring character in the series Beverly Hills, 90210, and Luke Perry's character's love interest; the character was killed off after a 10-episode storyline. Her feature film debut came in the comedy Nothing to Lose (1997) opposite Tim Robbins and Martin Lawrence, as a flower shop employee who woos an advertising executive. The same year, she had a minor role as a sorority sister in Wes Craven's horror film Scream 2.
After completing Scream 2, Gayheart was cast in a lead role in the slasher film Urban Legend (1998), playing the best friend of a college student (Alicia Witt) who suspects their friends are being murdered according to urban legends. The same year, she appeared onstage at Toronto's Canon Theatre in a production of The Last Night of Ballyhoo opposite Rhea Perlman and Perrey Reeves. In 1999, Gayheart starred in the black comedy film Jawbreaker with Rose McGowan, Julie Benz, and Judy Greer as girls in an exclusive clique in their high school who inadvertently kill their friend. The film was a box-office failure but later gained a cult following.
Gayheart starred in the video for Train's 1999 song "Meet Virginia".
In 2000, Gayheart had a lead role in the vampire film From Dusk Till Dawn 3: The Hangman's Daughter and a lead role in the thriller Shadow Hours, opposite Balthazar Getty. She also had a cameo appearance in Urban Legends: Final Cut, the sequel to Urban Legend. She followed this with an appearance in the independent comedy Harvard Man (2001).
In 2002, Gayheart was cast as Inara Serra on the TV series Firefly but left shortly after production began. The role was given to Morena Baccarin and none of Gayheart's work was used. Gayheart had recurring guest roles in the TV series Dead Like Me (2003), Nip/Tuck (2004–2006), and Vanished (2006).
From March to July 2005, Gayheart starred in a Broadway production of Steel Magnolias. David Rooney of Variety praised her performance, writing: "Exuding all the breezy confidence of a girl who's always been popular and pretty, Gayheart's Shelby provides a strong center, allowing only brief glimpses of the cracks in her cheerful, optimistic veneer and refusing to be treated as fragile goods by the clucking women around her." She also appeared in a minor role in the Christmas horror-comedy film Santa's Slay (2005). In 2007, Gayheart guest-starred on Ugly Betty as Jordan, an ex-girlfriend of Alexis Meade. In 2008, she returned to Broadway in a revival of the comedy Boeing-Boeing opposite Christine Baranski, Mark Rylance, Greg Germann, Paige Davis, and Missi Pyle. She had a guest role on The Cleaner in 2009.
Gayheart returned to film in 2013, reuniting with Jawbreaker director Darren Stein for his comedy G.B.F., portraying the mother of a gay teenage boy. She also starred opposite her husband, Eric Dane, in the thriller film Grey Lady, which was shot in 2014 and released in 2017.
In 2019, Gayheart returned to film with a minor supporting role in Quentin Tarantino's Once Upon a Time in Hollywood, playing Billie Booth, the ill-fated wife of Brad Pitt's character.
