Qvarqvare I Jaqeli (Georgian: ყვარყვარე I ჯაყელი) (1298 – 1361) was a Georgian prince (mtavari) and ruler of Samtskhe during 1334-1361.
His father was Atabeg Sargis II Jaqeli, the son of Beka I Jaqeli. In 1334, after his father's death, Qvarqvare became George V The Brilliant's vassal and was appointed as Atabeg of Samtskhe by King.