Isaac Wayne was an American politician from Pennsylvania who served as a Federalist Party member of the U.S. House of Representatives for Pennsylvania's 4th congressional district from 1823 to 1825. He previously served as a member of the Pennsylvania House of Representatives from 1799 to 1801 and in 1806, and served as a member of the Pennsylvania State Senate from 1807 to 1810.
- Occupation
- politician, lawyer
- Position held
- United States representative, member of the Pennsylvania House of Representatives, member of the Pennsylvania State Senate
- Citizenship
- United States
- Born
- 1772
