Foreign policy
In February 2022, Deputy Foreign Minister Gerardo Torres Zelaya held a meeting with Sahrawi President Brahim Ghali, which concluded with an announcement that diplomatic relations between the peoples and governments of Honduras and the SADR had been restored and would be deepened.
During her campaign, Castro promised to change Honduras' allegiance from the Republic of China (Taiwan) to the People's Republic of China if elected. Taiwanese Vice President Lai Ching-te attended Castro's inauguration. On 14 March 2023, Castro instructed her foreign minister to move to cut ties with Taiwan in order to establish formal relations with the People's Republic of China as the sole Chinese state. At the end of March, Honduras and the PRC formally established diplomatic ties and appointed ambassadors to their respective capitals.
Retired Taiwanese Kuomintang opposition member Tsai Cheng-yuan posted on social media that this move was a result of Taiwan refusing to shelter Castro during the 2009 coup. Castro for her part cited U.S. interventionism and pressure, especially in regards to Taiwan in Central America, as motives to open diplomatic relations with the People's Republic of China.
Shortly following Castro's inauguration, an event attended by representatives of the Nicolás Maduro government, the Venezuelan embassy in Tegucigalpa was vacated by representatives of Juan Guaidó, who had been recognised as the President of Venezuela by outgoing President Juan Orlando Hernández since the Venezuelan presidential crisis. As a result, the embassy was recovered by the Venezuelan delegation sent by the Maduro government. Former President and First Gentleman Manuel Zelaya responded to the news by sending a tweet welcoming Maduro, Latin American unity and the Bolivarian Revolution. Soon after, the Foreign Minister of Venezuela, Félix Plasencia, and newly appointed Foreign Minister of Honduras Enrique Reina announced the restoration of diplomatic relations between the two nations for the first time since 2009, when they were severed shortly after the coup. The restoration of diplomatic relations was followed by Honduran accreditation of the Venezuelan ambassador Margaud Godoy by Foreign Minister Reina, who said that if the United States had any uncertainty about Honduras' position, reestablishment of relations with Venezuela "for Honduras is a matter of sovereign foreign policy".
In January 2026, Castro condemned the United States' military intervention in Venezuela, which resulted in the capture of Nicolás Maduro.
Castro announced the recall of the Honduran ambassador from Israel on 4 November 2023, shortly after the country's ministry of foreign affairs stated that "Honduras energetically condemns the genocide and serious violations of international humanitarian law that the civilian Palestinian population is suffering in the Gaza Strip".
The United Nations General Assemblies (UN) are held in New York every September.
In her first speech before the UN, the president of Honduras, Xiomara Castro, demanded that Honduras's sovereignty and independence be respected by developed countries: "do not continue trying to destabilize Honduras, and dictate your measures or choose with whom we should relate", she said. She also held them responsible for environmental deterioration and for their participation in wars and financial crises: "This arbitrary world order, in which there are third- and fourth-rate countries, is unacceptable to us". In that context, she assured that her government would defend the environment. Castro blamed the United States for supporting a "narco-dictatorship" in the Central American country during the previous twelve years, in reference to the 12 years during which the right-wing National Party of Honduras held political power before the socialist Liberty and Refoundation Party, to which Castro belongs, came to office. The president referred to her predecessor, Juan Orlando Hernández, who at the time was facing trial for complicity in drug trafficking:
In Honduras we cannot continue sustaining the hypocrisy of a system that judges for crimes linked to drug trafficking the person whom, nevertheless, they backed and supported for more than a decade in the commission of crimes, two electoral frauds, and crimes against the homeland against millions of Hondurans.
Finally, she announced that she would establish relations with China and advocated for the regimes of Cuba and Venezuela:
We proclaim the return to the self-determination of peoples, rejecting the infamous and brutal blockade against the people of our sister Republic of Cuba. The aggression against the Bolivarian Republic of Venezuela must end.
For the second time, President Castro defended socialist regimes in Latin America:
We condemn the long blockade against Cuba and against Venezuela; likewise, we demand Cuba's removal from the list of countries classified as terrorists, because it is a manipulated, false and arbitrary measure... Unfair measures and sanctions against Nicaragua must also be removed, because they are barriers preventing us from normalizing our relations with our sister country.
Without mentioning Russia, she blamed global economic interests in Ukraine, in addition to recalling her opening of relations with China. She also referred to the situation in her country, accusing the political opposition and civil-society organizations of conspiring against her government, and specifically against the election of an attorney general. The accusation fell especially on the Citizen Opposition Bloc (BOC), an ephemeral coalition that sought to influence that election and which was made up of three opposition political parties: the major National Party and Liberal Party, and the Salvador of Honduras Party, to which Castro's main political ally and vice president, Salvador Nasralla, belonged. As achievements of her government, Castro said she had achieved a "reduction in extortion" and in homicides, pointing to the implementation of a state of exception. She also said that she had ordered "the greatest increase in the budget of the social sectors" and recalled the repeal of the ZEDEs (Zones for Employment and Economic Development) that Congress approved: "We repealed the ZEDE Law that split Honduran territory into 17 pieces to hand it over to 25 economic groups". Finally, she referred to the process of installing an International Commission against Corruption and Impunity in Honduras (CICIH):
I have delivered to the Secretary-General of the United Nations the official proposal of the agreement for the establishment of the CICIH, impartial, autonomous and independent. With the capacity to investigate and prosecute cases of high-impact corruption networks and financial crimes.
President Xiomara Castro began her speech by saying: "Today I am threatened by the same forces of capital that 15 years ago carried out a coup d'état against President Manuel Zelaya", accusing "the ten most powerful families in Honduras" of plotting against her. According to her speech, the destabilization attempts arose in response to her attempt to promote "structural changes to the economic model", specifically a new tax law that would no longer "perpetuate inequality". Castro again alleged interference in her country, maintaining what she had said days earlier when, under the same accusations, she decided to cancel the extradition treaty between her country and the United States (see: Xiomara Castro administration: foreign policy):
Our sovereignty is the fundamental basis and an undeclinable principle of international relations, but in Honduras colonial practices, interference, and economic, media and political domination continue to be imposed.
Castro said she had achieved in Honduras a "historic decrease of 15 points in homicides, the greatest reduction in the last 20 years". She repudiated the murder of environmentalist Juan López and said she had ordered that "the full capacity of the security forces" be used to capture those responsible. She also mentioned the delivery of a second draft agreement for the establishment of the CICIH and the by-then-defunct ZEDEs, declared unconstitutional by the Supreme Court after the National Congress did not ratify their repeal:
The international ZEDE project that sold our territory piece by piece as spoils for international capital, approved by stateless actors in the previous narco-regime, has been definitively cancelled by my government of democratic socialism.
Finally, she again advocated for Nicaragua and Venezuela, and against the United States embargo against Cuba. She condemned the genocide against Palestine and the recent Israeli attacks in Lebanon, hoping that it would not become a new Gaza Strip.