Plot
Former United Nations investigator Gerald "Gerry" Lane, his wife, Karin, and their two daughters, Rachel and Connie, are caught in traffic in downtown Philadelphia when a zombie outbreak hits. Escaping the ensuing chaos, they travel to Newark and rescue Tommy, a young boy whose family hunkered down in their apartment and refused to leave. They are rescued by a helicopter sent by Thierry Umutoni, the UN deputy secretary-general.
The group is then taken to a US Navy vessel stationed in the Atlantic Ocean, where a team of scientists study the outbreak. Among them is virologist Andrew Fassbach, who believes that the plague is caused by a virus and that finding its origin is crucial for developing a vaccine. Faced with the threat of his family's eviction from the vessel, Gerry reluctantly agrees to assist Fassbach.
Gerry, Fassbach, and a Navy SEAL escort fly to Camp Humphreys in South Korea, from where the first report of zombies was received. Upon arrival, the group is attacked by zombies, causing a panicked Fassbach to slip on the plane ramp and accidentally shoot himself dead. The team is saved by US soldiers stationed at the camp, and Gerry discovers that the infection was brought to the base by its doctor. A CIA officer imprisoned there guides Gerry towards Israel, where the Mossad has established a secure area.
In Jerusalem, Gerry encounters Jurgen Warmbrunn, a high-ranking Mossad official, who mentions that intercepted communications of Indian troops fighting zombies is what led Israel to set up defenses. Jerusalem has protected itself by constructing a massive wall, and allowing both israeli and palestinian refugees to seek shelter within the city. However, the refugees' loud celebrations attract zombies, which instinctively form massive castells to overcome the wall. As the city becomes overrun, Warmbrunn instructs Israeli soldiers to accompany Gerry back to his plane. Amidst the mayhem, Gerry observes zombies ignoring an elderly man and a malnourished boy. When one of Gerry's escorts, "Segen", is bitten on her hand, he amputates it to prevent her from turning into a zombie. Together, they escape on Belarus Airways Flight 160.
Gerry redirects the plane to a World Health Organization (WHO) medical research facility in Cardiff. During the journey, a stowaway zombie attacks a flight attendant, which later attacks the passengers. To eliminate the zombies, Gerry detonates a grenade to breach the cabin and expel them, resulting in the plane's crash landing. With Gerry presumed killed, his family is relocated from the carrier to Nova Scotia.
Gerry and Segen survive the crash, although Gerry is trapped in his seat and has sustained injuries. Segen comes to Gerry's aid, and together, they reach the Cardiff facility. Exhausted and wounded, Gerry loses consciousness and wakes up three days later, having been treated by the WHO staff. Sharing his observations, Gerry deduces that the zombies ignore the sick or injured, as they are not suitable hosts for spreading the infection. He proposes injecting healthy individuals with a curable pathogen as a form of "camouflage" against the zombies. The pathogen samples are in a section of the WHO facility infested with zombies. Gerry, Segen, and the head doctor attempt to sneak through the lab but accidentally alert the zombies. The three are separated in a chaotic chase, with Segen and the doctor forced to retreat. Gerry, the only one able to reach the samples, does so but is unable to leave because of a lone zombie blocking his path. Out of options, Gerry tests his theory by injecting himself with a pathogen. As he opens the door, his theory is proven correct: the zombie ignores him completely.
Gerry and Segen reach a secure area in Freeport, Nova Scotia, where Gerry reunites with Karin and the kids, including Tommy, who, having been orphaned, is unofficially adopted by Gerry and Karin. A vaccine is created, from a hybridised meningitis strain with components of smallpox and swine flu, serving as stealth against the zombies, enabling civilians to evacuate infected regions safely and empowering the military to combat the zombies more effectively.