Cast and characters
Hamza Haq as Dr. Bashir "Bash" Hamed, an emergency medicine resident at York Memorial Hospital. Due to issues around recognition of foreign credentials, he was unable to get a job with a hospital in the pilot, and instead works as a line cook at a Middle Eastern restaurant; however, he soon has an opportunity to prove his mettle when a serious accident occurs at the restaurant, and his training and experience in a war zone enables him to save lives, using emergency medical techniques that can be performed without conventional medical equipment, before the first responders arrive.
Laurence Leboeuf as Dr. Magalie "Mags" Leblanc, a driven emergency medicine resident with health and personal issues, who is struggling to stay on top of them in the high-stress environment of a hospital emergency room.
John Hannah as Dr. Jedediah "Jed" Bishop (seasons 1–2; guest season 4), the gruff but compassionate Chief of Emergency Medicine at York Memorial.
Ayisha Issa as Dr. June Curtis, a gifted trauma surgery resident who is emotionally guarded and struggles to open up; in the second season, she applies for and wins the job of chief resident.
Jim Watson as Dr. Theo Hunter, a pediatric emergency medicine fellow, later an attending physician from Sudbury who struggles with having to be away from his wife and kids while he completes his residency.
Sirena Gulamgaus as Amira Hamed, Bash's sister, who is twelve during season 1, and fourteen by season 3, episode 2.
Torri Higginson as Claire Malone, the head emergency nurse, later nurse practitioner, who is also in a romantic relationship with Jed.
Grace Lynn Kung as Vivian Barnes (season 1), the hospital's social worker.
Sugith Varughese as Dr. Aajay Singh, a general surgery attending physician.
Linda E. Smith as Dr. Wendy Atwater (seasons 1–2), the attending physician who is the residents' immediate supervisor.
Kenny Wong as Arnold Wong, an emergency nurse.
Mariah Inger as Rhoda DaSilva, an emergency nurse.
Eddie G. as Lou, a security guard at the hospital.
Eli Shankji as Saleh, Bashir's friend, a Syrian refugee working with Doctors Without Borders in Lebanon.
Fayçal Azzouz as Khaled (seasons 1–2), Bashir's friend, a Libyan refugee claimant in Canada.
Gord Rand as Dr. Mark Novak (seasons 2–4), the acting Chief of Emergency Medicine at York Memorial following Jed's stroke.
Nora Guerch as Rania (seasons 2–3), an old friend of Bash's from Syria whom he had believed for several years to be dead.
Atticus Mitchell as Jake Cooper (season 2), a medical student supervised by Theo.
Rekha Sharma as Dr. Neeta Devi (seasons 3–4), Bishop's replacement as chief of York Memorial's emergency department.
Ali Momen as Dr. Karim Esfahani (seasons 3–4), Bashir's therapist.
Marianne Farley as Dr. Elizabeth Bergeron (seasons 3–4), the attending physician who becomes supervisor of the ER department, and Theo's girlfriend.
Mark Rendall as Elliot (season 4), the doctor who sponsored Bashir and Amira to Canada.