Recurring cast
Ashley Ehrhardt (Lily Goff), Marly's daughter. (Seasons 1–5)
Kelsey (Marissa Blanchard), Lindsay's daughter. (Seasons 1–5)
Ali (Amy Farrington), quiet, shy, but witty gym worker. (Seasons 1–2, 4)
Mrs. Belt (Jordan Baker), Ritchie's third grade teacher. (Season 1)
Stan aka "Sad Dad" (Andy Richter), divorced father who Christine finds herself unable not to sleep with due to a sexual skill that earns him the title "champ". (Seasons 1–3)
Burton Schaefer (Matt Letscher), Old Christine's on-and-off romantic interest. (Seasons 1–2)
Pete (Anthony Holiday), ex-husband of Barb. At one point Barb and Pete split up temporarily before Barb realizes she doesn't like being alone. However, their marriage gradually dissolves off screen which leads to a bitter divorce during the third season. (Seasons 1–2)
Mrs. Wilhoite (Mary Beth McDonough), teacher and mean mom at the school. (Seasons 1–5)
Daniel Harris (Blair Underwood), Ritchie's former 4th grade teacher who is known for being unbelievably handsome. He dates Old Christine after he accepts an offer to teach at another school. Christine has been in love with him for a long time and although dating goes well, the relationship eventually fails due to Christine's time constraints. (Seasons 2–3, 5)
Jeff Hunter (Scott Bakula), also known as Papa Jeff, originally Christine's love interest, but she soon finds out he is New Christine's father and reluctantly dumps him. At New Christine and Richard's wedding, Jeff and Christine rekindle their relationship. Christine realizes shortly after this he is engaged. (Seasons 2, 4 and 5)
Mrs. Marcie Nunley (Nancy Lenehan), peppy principal of Ritchie's school. Lenehan, before recurring as Mrs. Nunley, guest starred in season one as a completely different character named Kit. (Seasons 2 and 5)
Tom (Dave Foley), Richard's work associate who has always had a crush on Old Christine. After he gets sick on their disastrous first date, they bond later in the series, though Christine is not attracted to him. Richard sets them up yet again, and this time Tom offers that Christine use him for his money and help, but Tom leaves her after he finds Christine's attempted seduction as "repulsive". (Seasons 2–3, 5)
Mike Gay (Tom Papa), Christine's only friend at Westbridge, as he is similar to Christine in that he is not wealthy and is also divorced. (Season 3)
Lucy (Michaela Watkins), a former patient of Matthew's who is attracted to authority figures. Matthew falls for her and after ending the therapist/patient relationship, the two begin to date. They fall in love and begin a much more serious relationship. They eventually move in together but Lucy's disturbing childlike quirks causes them to break up. (Seasons 4–5)
Patrick Harris (Tim DeKay), Old Christine's new boyfriend, who she meets in a video store and starts dating. Patrick turns out to have some serious rage issues when he "loses" at something, and Christine breaks up with him. (Season 4)
Principal Merrow (Stephen Tobolowsky), Westbridge Middle School's principal, who has very little tolerance for Old Christine's neurotic behavior. (Season 4)
Dave (James Lesure), a man Barb meets at Richard and New Christine's wedding. Although he originally tries to deport her as he is an INS agent, he later finds a way to keep her in the country because of his feelings for her. He later ends up being afraid of her and hating her personality as their relationship progresses. He proposes to her, believing that she will break up with him, but she ends up saying yes. (Seasons 4–5)
Max (Eric McCormack), Old Christine's therapist/crush and Matthew's mentor. Christine and Max share a mutual attraction, but Christine decides she needs a therapist more than she needs a boyfriend. Max has had his license suspended multiple times for getting too close to patients, but after he and Christine end their therapist sessions in order to date each other, he proves to be a calm and steady boyfriend. The two become engaged but Christine postpones their engagement so that she can go back to college. (Season 5)
