Recurring
Officials
Aaron Blakely as Erich Raeder (seasons 1–3), an SS-Sturmbannführer, John Smith's right-hand man
Carsten Norgaard as Rudolph Wegener (seasons 1, 3), a disillusioned high-ranking Nazi official who trades secrets with Tagomi and is friends with John Smith
Bernhard Forcher as Hugo Reiss (season 1), the German ambassador to the Japanese Pacific States
Aubrey Deeker as Kurt Scausch (season 1), a member of the SS working alongside Hugo Reiss
Neal Bledsoe as SS-Captain Connolly (season 1), an American SS officer serving under John Smith, later revealed to be a spy working for Reinhard Heydrich
Raresh DiMofte as Karl Müller (season 1), a SS-Sturmbannführer who was sent to San Francisco in order to assassinate the Japanese crown prince to provoke a war between the GNR and JPS
Sebastian Roché as Martin Heusmann (seasons 2–3), a high-ranking Reichsminister in the Nazi government and Joe Blake's biological father
Adrian Hough as Carl Weber (season 3), the Nazi ambassador to the JPS, replacing Hugo Reiss
Eric Lange as General Whitcroft (season 4), John Smith's second-in-command
Marc Rissmann as Wilhelm Goertzmann (season 4), an Obergruppenführer from Berlin
Civilians
Jessie Fraser as Rita Pearce (seasons 1–2), Joe's lover, who leaves him after finding out about Juliana
Carter Ryan Evancic as Buddy Pearce (seasons 1–2), Rita's son, who viewed Joe as a surrogate father
Kevin McNulty as Dr. Gerald Adler (seasons 1–2), John's family doctor who diagnosed Thomas
Gillian Barber as Alice Adler (seasons 2–3), Gerald's wife, who begins to become paranoid of the Smiths
Emily Holmes as Lucy Collins (seasons 2–3), a friend of Helen's and Juliana's
Kurt Evans as Henry Collins (season 2), Lucy's husband, who was executed during a broadcast for revealing Hitler's death
Giles Panton as Billy Turner (seasons 3–4), a Nazi Reich American advertising executive who is working with Nicole Dörmer to erase the memories of the former U.S. from the minds of the citizens in the Nazi Reich America
Laura Mennell as Thelma Harris (season 3), a closeted lesbian gossip column reporter in New York City
Jeffrey Nordling as Daniel Ryan (season 3), a Jungian therapist employed to treat Helen Smith's grief following the death of her son Thomas
Diane Greenwood as Fatima Hassan (season 3), a traveler from a parallel world who was captured by the Nazis
Charlie Hofheimer as Daniel Levine (season 4), John's Jewish friend who was executed after the Nazis took over America. In the alt-world, he is alive.
Rachel Nichols as Martha (season 4), Helen Smith's "wife-companion" assigned by the Reich to keep an eye on her
John Smith's family/household
Quinn Lord as Thomas Smith, John and Helen's son and the eldest child. A member of the Hitler Youth, it is later revealed that he has inherited a form of muscular dystrophy (facioscapulohumeral muscular dystrophy) from his father's side of the family. Learning this, he turns himself in to the Reich Sanitation Services and is euthanized. In season 4, Lord plays Thomas in an alternate universe in which the Axis lost the war.
Genea Charpentier as Jennifer Smith, John and Helen's daughter
Gracyn Shinyei as Amy Smith, John and Helen's daughter and youngest child
Meg Heus as Bridget (seasons 3–4), a maid of the Smiths in their new apartment
Rudolph Wegener's family
Stefanie von Pfetten as Kathrina Wegener (seasons 1–2), Rudolph's ex-wife
Jara Zeimer as Klaudia Wegener (season 1), Rudolph and Kathrina's daughter
Luke Roessler as Otto Wegener (season 1), Rudolph and Kathrina's son, who has an estranged relationship with his father
Officials
Lee Shorten as Hiroyuki Yoshida (seasons 1–2), a sergeant and Inspector Kido's right-hand man
Arnold Chun as Kotomichi, Tagomi's aide-de-camp, who came from the parallel world after his hometown, Nagasaki, was destroyed by an American atomic bomb
Daisuke Tsuji as the Crown Prince of Japan (season 1)
Mayumi Yoshida as the Crown Princess of Japan (seasons 1, 4)
Amy Okuda as Christine Tanaka (season 1), an office worker working in the Nippon Building
Tzi Ma as General Hidehisa Onoda (season 2), a leading member of the Japanese Army
Bruce Locke as General Yamori (season 4), a hardline Japanese general in favour of continuing the occupation of the JPS
Akie Kotabe as Nakamura (season 3), a Japanese-American sergeant of mixed ethnicity who works under Kido as Yoshida's replacement
Eijiro Ozaki as Admiral Inokuchi (seasons 3–4), an admiral and the head of the Imperial Japanese Navy fleet stationed in the San Francisco Bay
Sen Mitsuji as Toru Kido (season 4), Inspector Kido's son who suffers from PTSD
Rich Ting as Iijima (season 4), a Japanese captain
Civilians
Jack Kehler as Harlan Wyndam-Matson (season 1), the owner of the factory where Frank and Ed work
Frank C. Turner as Jim McCarthy (season 1), Ed's grandfather who dislikes the American resistance
Michael Eber as Doni (season 1), a person in the same aikido class as Juliana, who seems to have a crush on her
Hiro Kanagawa as Taishi Okamura (seasons 1–2), the leader of a Yakuza based in the Pacific States
Louis Ozawa Changchien as Paul Kasoura (seasons 1–2), a wealthy lawyer who collects prewar American memorabilia
Tao Okamoto as Betty Kasoura (season 1), Paul's wife
Michael Hagiwara as Okami (season 4), a Yakuza boss operating in the JPS
Chika Kanamoto as Yukiko (season 4), Childan's assistant and later wife
Juliana Crain's family
Daniel Roebuck as Arnold Walker (seasons 1–2), Juliana's step-father and Trudy's father
Macall Gordon as Anne Crain Walker (seasons 1–2), Juliana's mother who is still bitter about losing her husband in World War II
Conor Leslie as Trudy Walker (seasons 1–3), Juliana's half-sister who is shot dead by the Kempeitai. However, she is shown alive at the end of season 2, revealed in the third season to be from an alternate timeline in which it was Juliana who died.
Frank Frink's family
Christine Chatelain as Laura Crothers (seasons 1–2), Frank's sister, who is gassed in an attempt to pressure Frank into a confession
Darren Dolynski as Bill Crothers (season 1), Laura's husband and Frank's brother-in-law, who blames Frank for the death of Laura
Callum Seagram Airlie as John Crothers (seasons 1–2), Bill and Laura's son, gassed alongside his mother
Carmen Mikkelsen as Emily Crothers (seasons 1–2), Bill and Laura's daughter, gassed alongside her mother
Nobusuke Tagomi's family
Yukari Komatsu as Michiko Tagomi (season 2), Nobusuke's wife
Eddie Shin as Noriaki Tagomi (season 2), Nobusuke and Michiko's son, who is Juliana's husband in a parallel universe
Tamlyn Tomita as Tamiko Watanabe (seasons 3–4), an Okinawan-Hawaiian painter who befriends Tagomi
Mark Sampson's family
Yael Yurman as Clara Sampson (seasons 1–3), Mark's daughter
Ruairi MacDonald as Charlie Sampson (seasons 1–3), Mark's son
Allan Havey as the Origami Man (season 1), a Sicherheitsdienst (SD) operative sent to Cañon City to eliminate members of the Resistance
Burn Gorman as the Marshal (season 1), a bounty hunter searching for concentration camp escapees
Shaun Ross as the Shoe Shine Boy (season 1), a young albino man living in Cañon City
Rob LaBelle as Carl (season 1), a book store clerk in Cañon City who is revealed to be a concentration camp escapee, David P. Frees
Geoffrey Blake as Jason Meyer (season 1), a Jewish member of the Resistance
Shannon Day as Katie Owens (season 1), a woman who stole Juliana's bag at a bus stopover, which contained fake films
Janet Kidder as Lila Jacobs (season 3), one of the many Jews protected in a Catholic commune in the Neutral Zone, and also Mark Sampson's love interest
James Neate as Jack (season 3), a man in the Neutral Zone with whom Ed McCarthy becomes romantically involved
Michael Rispoli as Don Warren (season 1), the manager who gave Joe the mission to go to Cañon City, who is later executed by John Smith
Geoffery Blake as Jason "Doc" Meyer (season 1), a member of the American resistance working with Don Warren
Rick Worthy as Lemuel "Lem" Washington, the owner of the Sunrise Diner in Cañon City and member of the Resistance
Camille Sullivan as Karen Vecchione (seasons 1–2), a leader of the Pacific States branch of the Resistance
Hank Harris as Randall Becker (season 1), a member of the Pacific States branch of the Resistance
Cara Mitsuko as Sarah (season 2), a Japanese American Resistance member, Frank's confidante and a survivor of the Manzanar concentration camp
Tate Donovan as George Dixon (season 2), Trudy's biological father and a member of the resistance in New York City
Michael Hogan as Hagan (seasons 2–3), an ex-priest and leader in the San Francisco Resistance
Stephen Root as Hawthorne Abendsen / the Man in the High Castle (seasons 2–4), the head of the American resistance who formerly served the US Army Signal Corps, creating films set in other worlds
Ann Magnuson as Caroline Abendsen (seasons 3–4), Hawthorne Abendsen's wife
Clé Bennett as Elijah (season 4), Bell Mallory's lover and one of the members of the BCR
David Harewood as Equiano Hampton (season 4), the leader of the BCR
Wolf Muser as Adolf Hitler (seasons 1–2), the leader of the Greater Nazi Reich
Ray Proscia as Reinhard Heydrich (seasons 1–2), SS-Oberst-Gruppenführer
Keone Young as Shunroku Hata (season 1), a field marshal
Kenneth Tigar as Heinrich Himmler (seasons 2–4), Reichsführer-SS and later the new Führer
Lisa Paxton as Eva Braun (season 2), Hitler's wife
David Furr as George Lincoln Rockwell (season 3), the Reichsmarschall of German-controlled America
William Forsythe as J. Edgar Hoover (seasons 3–4), the director of the American Reich Bureau of Investigation (the counterpart of the Federal Bureau of Investigation)
John Hans Tester as Josef Mengele (seasons 3–4), the head of studies about trans-universe travel
Gwynyth Walsh as Margarete Himmler (season 4), Himmler's wife and the head of the Reich Red Cross
Timothy V. Murphy as Adolf Eichmann (season 4), SS-Oberst-Gruppenführer
Hiromoto Ida as Hirohito (season 4), the Japanese emperor