Sportscasting and podcasting career
Sharpe was a commentator for the CBS Sports pregame show The NFL Today, including the Sprint Halftime Report and the Subway Postgame Show, replacing Deion Sanders and co-hosting with James Brown (formerly with Fox NFL Sunday), former NFL quarterbacks Dan Marino and Boomer Esiason, as well as former coach Bill Cowher. In the 2004 NFL regular season, Sharpe defeated Marino and Esiason in the pick 'em game of The NFL Today with a 53–21 record. On February 18, 2014, it was announced that Sharpe, along with Dan Marino, were being relieved of their duties as on-air commentators on The NFL Today and were being replaced by Tony Gonzalez and Bart Scott.
In 2013, Sharpe became a columnist and spokesperson for FitnessRX For Men magazine and appeared on their September 2013 cover. Sharpe has hosted Sirius NFL Radio's Opening Drive morning program, alongside Bob Papa.
After his retirement, Sharpe has been a social media staple, going viral for his antics and sports commentary. He is also notably a huge supporter of NBA player LeBron James, referring to him as the greatest basketball player in NBA history. He also appeared on the American Dad! episode "The Scarlett Getter", portraying himself.
Sharpe joined Skip Bayless in FS1's sports debate show Skip and Shannon: Undisputed which premiered on September 6, 2016. In addition to his defense of LeBron James, Sharpe was also known for his criticism of Tom Brady and the Dallas Cowboys on the show. On May 31, 2023, it was announced that Sharpe would soon leave Undisputed after reaching a buyout agreement with Fox Sports. On June 13, Sharpe co-hosted his last episode of Undisputed. He later confirmed that he and Bayless had a falling out following an argument where Bayless compared Sharpe's NFL career to Tom Brady's.
Sharpe also has multiple podcasts: Club Shay Shay (which he hosts) and Nightcap (which he hosts with Chad Ochocinco Johnson and Joe Johnson). The episode of Club Shay Shay featuring Bubba Wallace was selected by the Apple Podcasts editorial team on their "Apple Podcasts Best of 2021" list. Both podcasts have been nominated for and won multiple awards for online media.
On August 23, 2023, it was announced that Sharpe and his Club Shay Shay podcast would join The Volume, a digital podcast network founded by Colin Cowherd under a multi-year deal. The following day, Sharpe was announced to join First Take on ESPN as a recurring panelist, beginning on September 4, 2023. He appeared every Monday and Tuesday during the 2023 NFL season. On February 16, 2024, Sharpe signed a contract extension to remain on the show. In June 2024, Sharpe had officially signed a new multi-year contract extension with ESPN which also allowed him to expand his role on First Take.
On September 12, Nightcap streamed The Roast of Shannon Sharpe, with special guests including Lavell Crawford, Kai Cenat, Godfrey, Cam Newton, and Snoop Dogg.
In February 2025, the "Club Shay Shay" podcast won the Outstanding Society and Culture Podcast at the 2025 NAACP Image Awards. He was also a nominee for Entertainer of the Year but was edged out by actress, singer and television personality Keke Palmer.
On April 24, 2025, Sharpe departed from ESPN for an unknown period of time amid a sexual assault lawsuit against him. Despite his intent to return to ESPN in time for the start of the NFL preseason, the amount of time that Sharpe will be on hiatus remains indefinite. On July 30, 2025, it was reported that ESPN cut ties with Sharpe after the settlement of the rape lawsuit.