2018–present
In 2018, Hüller became a member of the company at the Schauspiel Bochum, again working with Johan Simons, and played the lead role in Simons' adaptation of Penthesilea in Bochum and at the Salzburg Festival. In 2019, Hüller appeared in Johan Simons' award-winning, gender-switched version of Hamlet. In 2019, Hüller was part of the 69th Berlin International Film Festival's jury, chaired by Juliette Binoche. Later in 2019, she appeared in two French films, Justine Triet's Sibyl, where she played film director Mika, and in Alice Winocour's Proxima as the psychologist Wendy.
In 2023, Hüller portrayed Countess Irma Sztáray in Frauke Finsterwalder's historical black comedy film Sisi & I, a retelling of the later years of Empress Elisabeth of Austria from the point of view of her lady-in-waiting. The film had its world premiere at the 73rd Berlin Film Festival on 19 February 2023, and was released in Germany on 30 March 2023. Hüller was nominated for the German Film Award for Best Actress for her performance in the film.
In 2023, Hüller starred in two films that premiered in main competition at the 2023 Cannes Film Festival; the French legal drama Anatomy of a Fall by Justine Triet, which won the Palme d'Or, and the American-British-Polish Holocaust drama The Zone of Interest by Jonathan Glazer, which won the Grand Prix. Both films brought her international recognition. She won her second European Film Award for Best Actress for Anatomy of a Fall, while also being nominated for The Zone of Interest. She also earned Academy Award and Golden Globe nominations for Anatomy of a Fall, as well as BAFTA Film Award nominations for both Anatomy of a Fall and The Zone of Interest. She also won the César Award for Best Actress for Anatomy of a Fall.
In May 2024, Variety reported that Hüller would begin filming Late Fame in New York City that fall, starring alongside Willem Dafoe; by October, Greta Lee replaced her due to scheduling conflicts.
In April 2025, Hüller made her stage directorial debut, co-directing Penthesile:a:s by Marie Dilasser with Tom Schneider at the Neues Theater Halle as part of their FARN.collective.
In 2026, Hüller starred in Markus Schleinzer's Rose as a middle-aged woman disguised as a man, who appears in a secluded Protestant village. For her performance, Hüller received critical acclaim, winning the Silver Bear for Best Leading Performance. She also played the role of Eva Stratt in Phil Lord and Christopher Miller's Project Hail Mary, an adaptation of Andy Weir's 2021 novel of the same name. Hüller played the lead role as the daughter of German writer Thomas Mann in Fatherland, a drama by Pawel Pawlikowski which premiered at the 2026 Cannes Film Festival to critical acclaim.
Hüller will next star in the film Digger alongside Tom Cruise, which will release in October 2026.
