2020s
It was announced in 2019 that Campbell would star as author Laura Sobiech in the biographical musical drama film Clouds, which is based on the true story of Zach Sobiech. She detailed her experience in playing the role, saying that "I'd have some stuff to shed every evening, there were days of heavy crying, and I'd just be drained." It was released in 2020 to positive reviews on Disney+. Variety magazine described Campbell's acting as "well played within narrow bounds". IndieWire stated that she does "a fine job of balancing unimaginable pain with hard-fought moments of joy" and that she "distills Laura Sobiech's religious fervor into a more general desperation".
In September 2020, it was confirmed that Campbell would reprise her role as Sidney Prescott for the fifth Scream film, directed by Matt Bettinelli-Olpin and Tyler Gillett. She was initially "apprehensive" and hesitant to take the role given the death of Wes Craven; however, she was convinced to join once "the new directors came to me with this beautiful letter saying that they've become directors and love film because of these films, and because of Wes, and they really want to be true to his story and his journey with these films, so I was really happy to hear that." The film was released on January 14, 2022, and earned widespread acclaim. It was also a major commercial success, grossing over $135 million against a budget of $24 million. Campbell was lauded for her performance once more, and she was particularly praised for her "fresh" take on the role of Prescott. The Hollywood Reporter wrote that "... it's a pleasure to see Campbell again in fine form as Sidney, striding back into Woodsboro to take care of unfinished business". Elle magazine named her the "Reigning Queen of Scream" and stated that "Sidney might not have that impact on people were it not for Campbell's portrayal, rife with vulnerability, intelligence, and a palatable dose of humor."
In February 2021, Campbell was cast as Mickey Haller's ex-wife Maggie McPherson in a television adaptation of The Lincoln Lawyer for Netflix; The series premiered on May 13, 2022, and entered Netflix's Top 10 that same day. It was received positively by critics, and Lara Solanki of Radio Times felt that she was more "dogged and determined, qualities she showed once again in this year's Scream reboot" and said that giving the actress more screen time "would not be an unwelcome development". As of 2026, the show has run for four seasons, with a fifth season in development. In February 2022, Campbell signed with both the Gersh Agency and Anonymous Content.
Campbell was approached to reprise the role of Sidney Prescott in the sixth installment in the Scream franchise. At the Mad Monster Party Convention, she stated that "There's no script yet. There is a draft coming in soon is what I was told. Actually, I was supposed to call a producer yesterday, because he wanted to talk to me about what's going on. You know, we'll see. I'll read the script and see how I feel." In June 2022, it was announced she would not be returning to the Scream franchise after salary negotiations stalled with Paramount. She said she could not bear "walking on set and feeling undervalued" and that the offer would have been different had she been a man, stating that:
As a woman I have had to work extremely hard in my career to establish my value, especially when it comes to Scream. I felt the offer that was presented to me did not equate to the value I have brought to the franchise. It's been a very difficult decision to move on. To all my Scream fans, I love you. You've always been so incredibly supportive to me. I'm forever grateful to you and to what this franchise has given me over the past 25 years.
In May 2022, Campbell was cast as Raven in a recurring role for the Peacock television series adaptation of Twisted Metal. The series was released in July 2023 and The Hollywood Reporter said that she was "coming across as cheery in a way that's instantly suspicious". In August 2022, it was announced that Campbell had been cast in the lead role of the ABC series Avalon as Detective Nicole "Nic" Searcy. It was later announced in November that the series had been scrapped, though it was being shopped to other networks.
In July 2023, it was announced that Campbell would serve as executive producer of the documentary Swan Song. Profiling the final days of ballerina Karen Kain at the National Ballet of Canada, Campbell enjoyed working on the film as it tied into her previous ballet interest. Swan Song was selected to premiere in the Special Presentations line-up of the Toronto International Film Festival and was scheduled to have a 2024 theatrical release.
In March 2024, Campbell announced through her Instagram that she would reprise the role of Sidney Prescott in Scream 7. She was paid a salary of $7 million dollars. Shawn Robbins, a director of movie analytics at Fandango Media, said that "Neve Campbell is to Scream what Jamie Lee Curtis is for the Halloween franchise, she's a big draw, especially for older generations who grew up with the original films." The film was released in February 2026 to negative reviews but set the record for the highest opening weekend of the franchise, with Campbell's performance garnering praise.