Cast
Matthew Modine as Captain Dennis Dearborn, pilot: A humourless and socially inept perfectionist, he worked for his family's furniture business and named the titular plane after a woman he met in Memphis, Tennessee.
Eric Stoltz as Staff Sgt. (T/3) Danny "Danny Boy" Daly, radio operator: An earnest Irish-American, Daly was editor of the school paper, a valedictorian, and joined up right after graduating college.
Tate Donovan as 1st Lt. Luke Sinclair, co-pilot: The carefree and somewhat narcissistic former lifeguard, who wanted his own plane and is tired of being under Dearborn's command.
D.B. Sweeney as 1st Lt. Phil Lowenthal, navigator: Lowenthal is pessimistic and superstitious before their final mission, and is convinced that he is doomed to die.
Billy Zane as 1st Lt. Val Kozlowski, bombardier: While everyone believes the confident, self-assured Kozlowski to be a doctor, it is later revealed he attended only two weeks of medical school before enlisting.
Sean Astin as Staff Sgt. Richard "Rascal" Moore, ball turret gunner: Diminutive and often boastful, Rascal considers himself a ladies' man and delights in teasing his crewmates, especially Virgil.
Harry Connick Jr. as Staff Sgt. Clay Busby, tail gunner: After his father lost the family farm in a poker game, the laconic Busby earned money playing the piano in a New Orleans cathouse.
Reed Edward Diamond as Staff Sgt. (T/3) Virgil "Virge" or "Virgin" Hoogesteger, top turret gunner and flight engineer: He worked at his family's diner and plans to open a restaurant chain, while Rascal constantly mocks him for being a virgin.
Courtney Gains as Staff Sgt. Eugene "Genie" McVey, right waist gunner: A Catholic Irish-American from Cleveland who shares a cantankerous friendship with fellow waist gunner Bocci.
Neil Giuntoli as Sgt. Jack Bocci, left waist gunner: A hot-tempered Chicago hoodlum, Bocci shares a cantankerous friendship with fellow waist gunner McVey.
David Strathairn as Col. Craig Harriman, the sober-minded squadron commander who cares deeply for all his men.
John Lithgow as Lt. Col. Bruce Derringer, an Army publicist who plans to make the Memphis Belle crew famous for war propaganda.
Jane Horrocks as Faith, a British girl who has a fling with Virgil at a dance before the squadron's mission.
Mac McDonald as Les, a member of the squadron's ground crew.
Steve Mackintosh as Stan the Rookie, a nervous radio operator who is a crewmen on the new B-17, Mother and Country.