Margaretta is a feminine given name. It derives from Latin, where it came from the Greek word margaritari (μαργαριτάρι), meaning pearl, which was borrowed from the Persians. It is cognate with Margaret, Marguerite, and Margarita.
Notable people with the name include:
Margaretta Brucker (1883–1958), American fiction author
Margaretta Higford Burr, also known as Anne-Margaretta Burr (1817–1892), English watercolour painter
Margaretta Parker Cox, née Blair (fl. 1910s–1950s), second wife of politician James M. Cox and First Lady of Ohio
Margaretta Craig (1902–1963), American nurse and a missionary
Margaretta D'Arcy (1934–2025), Irish actress, writer, playwright, and activist
Margaretta Dressler, née Park (f. 1890s), wife of William F. Dressler
Margaretta Eagar (1863–1936), Irish woman who was a nanny to the daughters of the Emperor and Empress of Russia
Margaretta Faugères (1771–1801), American playwright, poet, and political activist
Margaretta Finch-Hatton, Countess of Winchilsea (1885–1952), American heiress
Margaretta Forten (1806–1875), African-American suffragist and abolitionist
Margaretta Foster, 1st Viscountess Ferrard (c. 1737–1824), Anglo-Irish peeress
Margaretta Graddon (born 1804), British popular singer
Margaretta Groark (fl. 2000s), The Amazing Race contestant
Margaretta Hicks (fl. 1880s–1910s), British socialist activist
Margaretta S. Hinchman (1876–1955), American artist, illustrator, photographer, and sculptor
Margaretta Elizabeth La Mott (fl. 1820s), wife of Alfred V. du Pont
Margaretta "Etta" Lemon (1860–1953), English bird conservationist and a founding member of the Royal Society for the Protection of Birds
Margaretta M. Lovell (fl. 1980s–2020s), American art historian
Margaretta Mitchell (born 1935), American photographer and writer
Margaretta Morris (1797–1867), American entomologist
Margaretta Palmer (1862–1924), American astronomer, one of the first women to earn a doctorate in astronomy
Margaretta Angelica Peale (1795–1882), American painter
Margaretta Riley (1804–1899), English botanist
Margaretta "Happy" Rockefeller, née Fitler (1926–2015), philanthropist and wife of vice president Nelson Rockefeller
Margaretta Salinger (1907–1985), American art historian and curator
Margaretta Schwartz (fl. 1870s), one of the first distinguished female performers in Yiddish theater
Margaretta Scott (1912–2005), English stage, screen and television actress
Margaretta Taylor (born 1942), American billionaire heiress
Margaretta Tuttle (1875–1958), American writer
Margaretta Wade Campbell, birth name of Margaret Deland (1857–1945), American novelist, short story writer, and poet
Margaretta Sully West (d. 1810), American stage actress and theater director