Toronto Blue Jays
In August 2016, Gurriel was declared a free agent by Major League Baseball (MLB), and ranked as the sixth best international prospect available. In September, he held a showcase of his skills at Rod Carew Stadium in Panama that was attended by 60 MLB scouts. On November 12, Gurriel signed a seven-year, $22 million contract with the Toronto Blue Jays. Gurriel took part in spring training with the Blue Jays, and was assigned to the Dunedin Blue Jays of the High-A Florida State League on March 17, 2017. Gurriel began the season on the disabled list with a leg injury. He made his minor league debut on April 18, but left the game with a recurrence of the same injury. On July 12, Gurriel was promoted to the New Hampshire Fisher Cats of the Double-A Eastern League after appearing in 18 games for Dunedin. In total, Gurriel played in 64 games in 2017 and hit .229 with five home runs and 36 RBI. He played for the Peoria Javelinas of the Arizona Fall League (AFL) during the offseason.
Gurriel began the 2018 season with New Hampshire. He batted .347 in 12 games, and was promoted to the major leagues on April 20. In his debut that night, Gurriel recorded two singles and three RBI. On April 28, Gurriel hit his first career home run, against Bartolo Colón of the Texas Rangers. On July 27, Gurriel recorded his first multi-home run game by hitting two home runs in a 10–5 win over the Chicago White Sox. By collecting a pair of singles in Toronto's game against the White Sox the following night, Gurriel became the first rookie in baseball's modern era to have 10 consecutive multi-hit games. The last rookie to accomplish this feat was Shoeless Joe Jackson in 1911. On July 29, Gurriel broke Jackson's rookie record with his 11th consecutive multi-hit game. Jackson also set the overall AL record with an 11-game multi-hit streak in 1912. Simultaneous with breaking Jackson's 1911 rookie record, Gurriel also tied Jackson's all-time AL record. However, on his third hit of the game on July 29, Gurriel was injured, and was subsequently put on the disabled list. On September 25, Gurriel was shut down for the rest of the season with a sore left hamstring.
After starting the 2019 season hitting .175 in 13 games and struggling with throws from second base, the Blue Jays optioned Gurriel to the Buffalo Bisons of the Triple-A International League. At Buffalo, Gurriel began playing as an outfielder. On offense, he finished the 2019 hitting .277 with 20 home runs in 84 games for the Blue Jays. On defense, he led all major league left fielders in assists, with 9.
Overall with the 2020 Blue Jays, Gurriel batted .308 with 11 home runs and 33 RBI in 57 games, and was named one of three finalists for the Gold Glove. In 2021, Gurriel set career highs on offense, hitting .276 with 21 home runs and 84 RBI in 141 games with Toronto. He also set a club record for most grand slams(4) in a season, including a game-tying slam against the Oakland Athletics on September 5. He also led all left fielders with 12 assists and was named a finalist for the Gold Glove Award for the second consecutive year.
On July 22, 2022, in a game in which the Blue Jays defeated the Boston Red Sox 28–5, Gurriel recorded six hits with five RBI. The accomplishment matched the franchise single-game record for hits, tying Frank Catalanotto who achieved the feat in 2004.
