Cast
Maia Kealoha as Lilo Pelekai, an orphaned six-year-old Native Hawaiian girl "who loves hula, surfing, and wildlife, with a special affinity for all things 'gross'." She is very imaginative yet rebellious and impulsive, which gets her into trouble often.
Sydney Elizebeth Agudong as Nani Pelekai, the older sister of Lilo and her legal guardian. She is described as "intelligent, overachieving, athletic, Type A" and a "straight-A student" who has been feeling the increasing pressures of having to take care of Lilo, causing issues with her and Lilo's social worker, with child protective services threatening to separate the Pelekai sisters and put Lilo into foster care.
Chris Sanders as the voice of Stitch, a blue koala-like illegal alien genetic experiment known as Experiment 626, who is adopted by Lilo as a "dog". He is described as "unruly, impulsive, and freakishly strong; he's a furry, ugly-cute wrecking ball seemingly bent on destroying everything in his path." Sanders, who wrote and directed the original animated film alongside Dean DeBlois, created the character and originated the role.
Zach Galifianakis as the voice of Dr. Jumba Jookiba, the mad scientist who created Stitch. He is more malicious in this film compared to his traditionally-animated counterpart and speaks with an American accent instead of a Russian accent.
Galifianakis also physically portrays "Marcus", Jumba's human disguise based on a hotel employee with that name.
Billy Magnussen as the voice of Agent Wendell Pleakley, a deputized agent of the United Galactic Federation and their "expert" on Earth, sent to prevent Jumba from harming any humans while hunting Stitch.
Magnussen also portrays Pleakley's human disguise, which is based on an unnamed human who was interacting with the real Marcus when Jumba and Pleakley copied their appearances.
Courtney B. Vance as Cobra Bubbles, a CIA agent sent to capture Stitch. While he is not the Pelekais' social worker in this film, he goes undercover as a social director after finding out about Stitch being with the Pelekais.
Amy Hill as Tūtū, a Native Hawaiian in her 70s who is the long-time neighbor of the Pelekais and the grandmother of David Kawena. She is described as "a warm, quick-witted woman who speaks with a local Pidgin accent". She is original to this film. Hill previously voiced Mrs. Hasagawa in the original film and Lilo & Stitch: The Series. In Hawaiian culture, the word "tutu" is commonly used to refer to grandparents.
Tia Carrere as Mrs. Kekoa, a social worker who is "a practical, by-the-book kind and patient woman who checks in regularly with Nani", but is nevertheless aware of Nani's struggles to keep up with her duties. Carrere previously voiced Nani in Lilo & Stitch animated media.
Kaipo Dudoit as David Kawena, a fire performer and lifeguard who is a loyal friend and neighbor to Lilo and Nani. He performs the "fire knife dance" at the lūʻau where he and Nani work at. Kahiau Machado was originally cast in the role, but he was recast shortly thereafter due to his prior usage of a racial slur.
Hannah Waddingham as the voice of the Grand Councilwoman, the grey alien leader of the United Galactic Federation and its council who orders Jumba and Pleakley to capture Stitch after his escape.
Jason Scott Lee as the manager for the resort lū'au Nani and David work at called "Jimmy's Luau". Lee previously voiced David in the original film and Lilo & Stitch 2: Stitch Has a Glitch (2005).
Celia Kenney as AJ, an animal shelter worker
Skyler Bible as Agent Foster, a CIA agent
Judy Nguyen as Agent Huynh, a CIA agent
Christian Yeung as Agent Zhao, a CIA agent
Emery Hookano-Briel as Mertle Edmonds, Lilo's hula classmate and bully
David Hekili Kenui Bell (credited as David H.K. Bell) as the "Big Hawaiian Dude", based on the non-speaking "Ice Cream Man" from the animated productions. This version of the character is a native Hawaiian as opposed to a sunburned Caucasian tourist and eats and drops shave ice instead of ice cream while audibly expressing surprise over Pleakley's real appearance being briefly revealed and later Jumba's spaceship flying by. This was Bell's final role before his death on June 12, 2025.
Mike Mitchell as the voice of the Hammerhead Guard, an unidentified hammerhead shark-like alien who originally guarded Stitch.
Karly McGowan as the voice of the Adorable Psycho, an unidentified axolotl-like alien who wants to blow up Earth.
Ashley Lambert as the voice of the ship
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