1981–2021
In the early 1980s, Powell toured in the comedies Same Time, Next Year; The Marriage-Go-Round, and Chapter Two.
Between 1981 and 1982, Powell had guest-starring role on The Love Boat and Fantasy Island. In 1985, she started a 9-month run in the daytime soap opera Loving, playing a tough mother and businesswoman, followed by another guest-starring part on Murder, She Wrote in 1985. In 1988, Powell was cast in a recurring guest role on the popular sitcom Growing Pains, in which she played Irma Seaver, the mother of Dr. Jason Roland Seaver (Alan Thicke). The same year, in May 1988, Powell married her longtime companion, former child actor Dickie Moore. The couple had met while Moore was performing research for his autobiography Twinkle, Twinkle, Little Star, but Don't Have Sex or Take the Car.
In the early 1990s, Powell was a temporary replacement on the soap opera As the World Turns for Eileen Fulton as Lisa Grimaldi. In 1996 and 1997, she appeared in the off-Broadway production After-Play. She also performed the role of the Queen in Rodgers and Hammerstein's Cinderella at New York City Opera. In 2000, Powell appeared in the Off-Broadway production Avow, in which she portrayed a devout Catholic woman whose gay son wishes to marry his partner in the church. This was followed by a stage production of 70, Girls, 70, the same year. In 2002, she guest-starred on Law & Order: Special Victims Unit, followed by a role in the Showtime film The Sandy Bottom Orchestra (2003).
In 2003, she made a return to the stage as Mama Mizner in the Stephen Sondheim musical Bounce, which held performances in Chicago and Washington, DC. "I auditioned just to meet Sondheim, who was nice and a very funny man,” Powell admitted. "But I was disappointed when I got the part. I didn't really want to be away from home, but I had never done a new show and that seemed exciting at first. But I didn't have much to do and the part wasn't too jovial."
On New Year's Eve 2007, Powell returned to her hometown of Portland, Oregon, to narrate Sergei Prokofiev's Peter and the Wolf with the Portland-based musical group Pink Martini. She also appeared on March 9, 2008, with Pink Martini at Avery Fisher Hall in New York City, singing a duet of "Aba Daba Honeymoon" with lead singer China Forbes.
In March 2009, she appeared and sang "Love Is Where You Find It" in a show in which Michael Feinstein celebrated movie musicals and MGM musicals in particular. She performed again with Pink Martini at the Hollywood Bowl on September 10, 2010. Powell filled in as guest host on Turner Classic Movies for Robert Osborne when he was on medical leave from July 17–23, 2011.