2011–present
On February 23, 2011, Franco made a cameo appearance on NBC's Minute to Win It where the real-life Ralston was participating as a contestant playing for charity. After having a cameo in the opening scene of The Green Hornet (2011), he starred opposite Natalie Portman and Danny McBride in the Medieval fantasy comedy Your Highness. In the film, he plays Fabious, a prince who teams up with his brother (McBride) to rescue the soon to be bride of Fabious (played by Zooey Deschanel). In May 2010, he was cast to star in Rupert Wyatt's $93 million budgeted Rise of the Planet of the Apes, a reboot of the Planet of the Apes series which was released on August 5, 2011. Franco starred alongside Winona Ryder in The Letter, originally entitled The Stare, directed by Jay Anania. He was cast as a drug-addicted lawyer in About Cherry, also starring Heather Graham, which started shooting the following month in California. He dropped out of the indie film While We're Young to star in Oz the Great and Powerful, a Disney prequel to L. Frank Baum's The Wonderful Wizard of Oz (1900). Filming began in July 2011, and the film was released on March 8, 2013. He has signed to appear in a sequel to it.
At the end of September 2010, the actor acquired the rights to Stephen Elliott's The Adderall Diaries, with the intention to adapt, direct, and star in the film. It was announced in January 2011 that the actor has planned to not only star in, but direct himself in The Night Stalker, a film version of author Philip Carlo's book about the 1980s serial killer, Richard Ramirez. Co-screenwriter of the screenplay, Nicholas Constantine, was initially unconvinced that Franco would be right for the movie, until he learned of Franco's desire to be a director and later watched three of his short films, one of which featured a serial killer, ultimately confirming to the writer that the actor had a darker side. Franco also directed a film version of William Faulkner's novel As I Lay Dying; the film was screened in the Un Certain Regard section at the 2013 Cannes Film Festival. In late 2013, Franco starred in This Is the End as a fictionalized version of himself stuck in a house during an apocalypse with Seth Rogen, Jay Baruchel, Craig Robinson, Jonah Hill, and Danny McBride, also fictionalized versions of themselves.
In February 2012, Franco began shooting a film version of Cormac McCarthy's 1973 novella Child of God, which stars Scott Haze as Lester Ballard. The film chronicles the depraved and violent impulses of the young Tennessee backwoodsman after he is dispossessed of his ancestral land. Child of God was selected in official competition at the 70th Venice Film Festival, an official selection to the 2013 Toronto International Film Festival and an official selection to the prestigious 51st New York Film Festival. In 2013, Franco starred as the gangster "Alien" in Harmony Korine's Spring Breakers, with Vanessa Hudgens, Selena Gomez, Ashley Benson, Gucci Mane and Rachel Korine. A24 films began a campaign in September 2013 in support of a Best Supporting Actor Oscar nomination for Franco's performance. In March 2013, it was announced that Franco was set to make his 2014 Broadway stage debut in the role of George in a revival of John Steinbeck's Of Mice and Men. In October 2013, Franco appeared in the music video for "City of Angels" by Thirty Seconds to Mars.
On March 8, 2013, Franco received a star on the Hollywood Walk of Fame, located at 6838 Hollywood Boulevard.
In April 2014, Franco directed and appeared in "Techno Color Sunglasses", which promoted Gucci's eyewear collection. In December, Franco starred in the controversial Sony comedy thriller, The Interview, a film which played a central role in the real world diplomatic relations between the United States and North Korea as they related to the 2014 Sony hacking incident. In April 2015, two of his projects, titled I Am Michael and True Story, were shown at the 2015 Sundance Film Festival. In I Am Michael, Franco plays a gay activist who rejects his homosexuality and becomes a conservative Christian pastor with a girlfriend. In True Story, based on a true story, Franco played Christian Longo, a man who was on the FBI's most wanted list for murdering his wife and three children in Oregon, and who had also been hiding under the identity of Michael Finkel, a journalist played by Jonah Hill.
In 2015, Franco was cast in the lead role for the Hulu limited series 11.22.63 which is based on the novel of the same name by Stephen King. The eight-episode series premiered on February 15, 2016. In 2016, Franco co-produced and starred in King Cobra, a true story about the rise of gay pornographic actor Brent Corrigan and the murder of Bryan Kocis. Franco played Joseph Kerekes who (along with his partner) was convicted of the murder. In the comedy Why Him?, released in December 2016, Franco played an immature tech-billionaire whose girlfriend's conservative father tries to intervene in the couple's relationship, with Zoey Deutch playing the girlfriend and Bryan Cranston as her father. He briefly appeared in the Alien prequel, Alien: Covenant, alongside his longtime friend and frequent collaborator Danny McBride, as well as Michael Fassbender and Noomi Rapace. He played Branson, the captain of the Covenant ship and husband to Daniels, played by Katherine Waterston. The film was released on May 19, 2017.
In 2016, Franco directed, co-produced, and starred in The Disaster Artist, the film adaptation of actor Greg Sestero's non-fiction book of the same name, about the making of The Room, which is considered to be one of worst films ever made. In the film, Franco portrayed the film's star, director, screenwriter, and producer Tommy Wiseau, while Franco's brother, Dave, portrayed Sestero. Franco remained in character as Wiseau throughout the entirety of the shoot. The Disaster Artist was released on December 1, 2017, to positive reviews, while his portrayal of Wiseau gained near-universal praise. His performance won a Golden Globe Award for Best Actor – Motion Picture Musical or Comedy.
At the end of 2017, Franco, almost 40, said he was slowing down to focus on himself.
On December 23, 2021, Franco gave his first interview in nearly four years when he appeared on an episode of the Jess Cagle Podcast. In August 2022, Franco was cast as Fidel Castro in Alina in Cuba (later retitled Castro's Daughter), a casting decision that was supported by Fidel Castro's daughter.
In October 2024, Hey Joe starring Franco premiered at the Rome Film Festival, and the film opened in Italian cinemas on November 28, 2024.
Franco also appeared in 2024 in the French thriller The Price of Money: A Largo Winch Adventure.
In May 2025, Deadline reported that Lionsgate’s partner Grindstone acquired U.S. distribution for the true-crime feature Golden State Killer (retitled from The Policeman), with Vincent Gallo as serial killer Joseph James DeAngelo and Franco as the detective trying to catch him.