Ultimate Fighting Championship (2014–2026)
Covington made his promotional debut against Anying Wang on August 23, 2014, at UFC Fight Night 48. He won the fight by TKO via punches in the closing seconds of the first round.
Covington fought Wagner Silva on November 8, 2014, at UFC Fight Night 56. He won the fight via submission in the third round.
Covington next faced Mike Pyle on May 23, 2015, at UFC 187, replacing an injured Sean Spencer. He won the fight via unanimous decision.
Covington faced Warlley Alves on December 12, 2015, at UFC 194. He lost the fight via submission in the first round.
Covington was expected to compete against Alex Garcia on June 18, 2016, at UFC Fight Night 89. However, Garcia was pulled from the fight on June 10 for undisclosed reasons and replaced by promotional newcomer Jonathan Meunier. Covington won the fight via submission in the third round.
Covington next faced promotional newcomer Max Griffin on August 20, 2016, at UFC 202. He won the fight via TKO in the third round.
Covington's next bout was against Bryan Barberena on December 17, 2016, at UFC on Fox 22. He won the fight via unanimous decision.
Covington faced Dong Hyun Kim on June 17, 2017, at UFC Fight Night 111. He won the fight via unanimous decision.
As the final fight of his prevailing contract, Covington fought Demian Maia on October 28, 2017, at UFC Fight Night 119. He won the fight via unanimous decision.
Covington fought Rafael dos Anjos on June 9, 2018, at UFC 225 for the Interim UFC Welterweight Championship. He won the fight via unanimous decision.
Covington was briefly linked to a title unification bout with the then champion Tyron Woodley on September 8, 2018, at UFC 228. However, Covington was unable to compete on that date due to recent nasal surgery. As a result, UFC officials turned their attention to arranging a bout between Woodley and Darren Till to fill the headlining spot. In turn, promotional officials indicated on July 24 that Covington would be stripped of the Interim UFC Welterweight Championship, once the bout between Woodley and Till took place.
Covington returned to face Robbie Lawler in the main event of UFC on ESPN 5 on August 3, 2019. He won the fight via a lopsided unanimous decision, setting a record for the most strikes thrown in a UFC bout, with 541 strikes.
Covington faced Kamaru Usman for the UFC Welterweight Championship on December 14, 2019, at UFC 245. Covington was finished by technical knockout in the fifth round. This fight earned him his first post–fight bonus in the UFC for Fight of the Night. Going into the final round, one judge had Covington winning 39–37, another had it tied at 38–38, and the other had it 39–37 in favor of Usman.
After a long-lasting, public feud and trash talking between Covington and other American Top Team members – most notably Dustin Poirier, Jorge Masvidal and Joanna Jędrzejczyk – Covington eventually parted ways with his first mixed martial arts gym in May 2020.
Covington headlined UFC Fight Night 178 against his long-time rival Tyron Woodley on September 19, 2020. After dominating his opponent for four rounds, the bout was called as a technical knockout when Woodley suffered a rib injury.
Covington rematched Kamaru Usman for the UFC Welterweight Championship on November 6, 2021, at UFC 268. Despite a close bout, Covington lost via unanimous decision.
Covington faced Jorge Masvidal on March 5, 2022, at UFC 272. He won the fight via unanimous decision in dominant fashion. This fight earned him the Fight of the Night award.
Covington successfully weighed in on March 17, 2023, as the backup for the welterweight title fight at UFC 286 in London, England.
After sitting out for nearly two years, Covington returned to face Leon Edwards for the UFC Welterweight Championship on December 16, 2023 in the main event at UFC 296. Covington broke his foot in the first minute of the bout, and eventually lost via unanimous decision.
Covington stepped in as a replacement for Ian Machado Garry, to face Joaquin Buckley on December 14, 2024, at UFC on ESPN 63. Covington lost the fight by technical knockout as a result of a doctor stoppage due to a cut above his eye in the third round.
On May 19, 2026, Covington officially notified the UFC of his retirement from mixed martial arts.