Women's suffrage
Despard was a vocal supporter of the Social Democratic Federation and the Independent Labour Party. In 1906 she joined the National Union of Women's Suffrage Societies and later was imprisoned four times for activism on women's franchise, twice in the Holloway prison. She had become frustrated with the lack of progress from NUWSS and she joined the more radical Women's Social and Political Union (WSPU). She became one of their recognised orators and described as a 'tireless and popular leader.. a striking figure with her thin sharp features and grimly tight lips'
In January 1907, Despard welcomed suffragettes just released from Holloway Jail. According to her, the occasion was "joyful". The meal took place in the Anderton Hotel, and others present included Christabel Pankhurst, Flora Drummond, Ann Fraser and Ivy Heppel.
In 1907, Despard was one of the women who formed the Women's Freedom League (WFL) whose motto was 'Dare to be Free', after disagreements over the autocratic way in which the WSPU was run.
She was an active Catholic and on Ash Wednesday in 1907, she went with others to the House of Commons and got arrested. In establishing WFL, Despard was joined by Teresa Billington-Greig, Bessie Drysdale, Edith How-Martyn, Alice Abadam, Marion Coates-Hansen, among others, as signatories to a letter to Emmeline Pankhurst explaining their disquiet on 14 September 1907. In 1911, when first imprisoned with Nina Boyle, Despard was furious when someone paid the fines, allowing them to be released right away; Boyle remarked upon her 'complete and absolute fearlessness'.
Sylvia Pankhurst, imprisoned with Despard in 1907, remarked at her death that "She was one of our most courageous and devoted social workers. When I was in prison with her in 1907, I was impressed by her truly magnificent courage". She was one of the imprisoned women who had a tree planted in the 'suffragettes' rest' of the Blathwayts in Batheaston, Eagle House.
Despard was closely identified with new passive resistance strategies including women chaining themselves to the gate of the Ladies' Gallery in the Palace of Westminster; and was one of those leading a "no taxation without representation" campaign, during which her household furniture was repeatedly seized in lieu of fines, along with Virginia Crawford, as she realised that the women's movement groups had to work together at times as well. She led the delegation at the Women's Coronation Procession (1911).
In 1909, she met Mahatma Gandhi in London, in her role in the Women's Freedom League. In 1912, at the seventh annual conference of WFL, she was pictured being greeted by Agnes Husband. The following September, she was with Agnes Husband again on the platform at Regent's Park.
In 1914, she spoke along with Anna Munro and Georgiana Solomon at the WFL Hampstead branch 'at home', hosted by Myra Sadd Brown, raising funds for the Women's Suffrage National Aid Corps. which Despard had founded.
From 1915 onward, she worked with Agnes Harben and others to maintain international women's movements representation in Britain. In 1919, she was one of twenty British delegates to the Women's International League Congress in Zurich (12–17 May). She is pictured next to Helen Crawfurd from Glasgow. She kept in communication with other suffragists, such as Daisy Solomon.
In 1928, Despard was one of the suffrage movement leaders at the celebratory breakfast for the passing of the Equal Franchise Bill.