Career
After graduating from college, Wong first tried stand-up comedy when she was 23. She soon moved to New York City to pursue comedy and began performing as often as nine times in one night.
In 2011, Variety named her one of the "10 Comics to Watch". Soon after, she appeared on The Tonight Show, John Oliver's New York Stand Up Show and Dave Attell's Comedy Underground Show. She was also cast as series regular in the NBC comedy series Are You There, Chelsea? and appeared on Chelsea Lately. Next, she was in VH1's Best Week Ever, and MTV's Hey Girl in 2013. Additionally, she starred in Oliver Stone's Savages, and as Kate in the film Dealin' with Idiots.
In 2014, Wong played Dr. Lina Lark in the ABC medical drama series Black Box, opposite Kelly Reilly and Vanessa Redgrave. She guest-starred in three episodes of Inside Amy Schumer. Wong worked as a writer on Fresh Off the Boat, which premiered in 2015. Randall Park, who was a main cast member, had suggested Wong for the writing role. On Mother's Day 2016, Netflix released a stand-up special called Baby Cobra; the special was filmed at the Neptune Theater in Seattle in September 2015, when Wong was seven months pregnant with her first child. According to New York Magazine, "The special's arrival on Netflix is the sort of star-making moment that unites the tastes of the unlikeliest fans".
On September 11, 2016, Wong spoke at, and walked the runway during New York Fashion Week for Opening Ceremony's show. Also in 2016, Wong starred in the ABC sitcom American Housewife until its cancellation in 2021. In 2018, Wong's second Netflix special, Hard Knock Wife, was released. It was filmed in 2017 at the Winter Garden Theatre in Toronto when she was seven months pregnant with her second child. In the same year, she voiced the character Citrus Twisty, a soda genie, in an episode of OK K.O.! Let's Be Heroes.
Wong starred with Randall Park in the 2019 Netflix film Always Be My Maybe, a film directed by Nahnatchka Khan, and written by Wong, Park, and Michael Golamco. From 2019 to 2022, Wong voiced Bertie in the Netflix/Adult Swim animated sitcom Tuca & Bertie. On October 15, 2019, Wong published a book entitled Dear Girls: Intimate Tales, Untold Secrets and Advice for Living Your Best Life. She described it as a life guide for her daughters to read when they become adults. The book won the 2019 Goodreads Choice Award for Humor. In February 2022, Wong released her third Netflix stand-up special, Don Wong.
Wong co-starred with Steven Yeun in the 2023 Netflix drama-comedy series Beef, and was credited as an executive producer alongside Yeun. For her performance in Beef, Wong received a Golden Globe Award for Best Actress – Miniseries or Television Film. She was the first actress of Asian descent to win a Golden Globe in the category. Wong won a Primetime Emmy Award for Outstanding Lead Actress in a Limited or Anthology Series or Movie making her the first actress of Asian descent to win a lead acting Emmy Award in this category.
In October 2024, Wong was featured on the YouTube talk show Hot Ones.